In individuals who are deficient in CYP2D6, coadministration of modafinil with substrates of CYP2D6 which have ancillary routes of elimination via CYP2C19 (eg, tricyclic antidepressants and selective serotonin reuptake inhibitors) may perhaps lead to elevated circulating levels of these drugs and need dose adjustment (Robertson et al 2000; PROVIGIL

Sebban C, Tesolin-Decros B, et al. Contrasting EEG profiles elicited by antipsychotic agents during the prefrontal cortex on the aware rat: antagonism of the results of clozapine by modafinil.Modafinil’s effects on regional activation seem like depending on baseline activation in the two paradigms, rising Daring sign in These with very low baseli